In recent years, aesthetic medicine has shifted away from simply filling wrinkles toward improving skin quality itself.
Treatments like polynucleotides and Profhilo are part of this new generation of regenerative injectables. Instead of adding volume like traditional dermal fillers, they work by stimulating the skin's own repair processes.
Because both treatments improve hydration, elasticity, and overall skin texture, many clients ask:
"What's the difference between polynucleotides and Profhilo?"
While they share similar goals, they work in very different ways.
Understanding those differences can help you decide which treatment may be more suitable for your skin.
What Is Profhilo?
Profhilo is a type of injectable treatment known as a bio-remodelling skin booster.
It contains one of the highest concentrations of hyaluronic acid available in aesthetic medicine.
Hyaluronic acid is a substance naturally found in the skin that helps retain moisture and maintain hydration.
When injected into specific points of the face, Profhilo spreads beneath the skin and stimulates:
- •collagen production
- •elastin production
- •deep hydration
Instead of creating volume like a filler, Profhilo works to improve the overall quality of the skin.
This makes it particularly popular for people experiencing:
- mild skin laxity
- dull or dehydrated skin
- early signs of ageing
The result is often described as smoother, more luminous skin with improved elasticity.
What Are Polynucleotides?
Polynucleotides are a newer type of regenerative injectable treatment designed to repair and rejuvenate the skin at a cellular level.
They are derived from highly purified DNA fragments that support the skin's natural regeneration processes.
When injected into the skin, polynucleotides help stimulate:
- •fibroblast activity
- •tissue repair
- •collagen production
- •improved skin elasticity
One of the key benefits of polynucleotides is their ability to improve the skin's healing and regeneration capacity.
Because of this, they are often used in areas where skin quality is particularly delicate, such as:
- under the eyes
- around the mouth
- the neck
Polynucleotides can also help improve skin texture, fine lines, and overall skin resilience.
Watch a Profhilo Treatment
Key Differences Between Polynucleotides and Profhilo
Although both treatments aim to improve skin quality, they work through different mechanisms.
Profhilo focuses primarily on deep hydration and skin bio-remodelling, using hyaluronic acid to improve moisture levels and stimulate collagen production.
Polynucleotides, on the other hand, focus more on cellular regeneration and tissue repair, encouraging the skin to rebuild itself from within.
Another difference lies in how the treatments are distributed beneath the skin.
Profhilo is typically injected into five specific points on each side of the face, allowing the product to spread naturally across the treatment area.
Polynucleotides are usually injected in a more targeted pattern, depending on the area being treated.
Which Treatment Is Better?
There is no single "better" treatment.
Instead, the right option depends on your skin concerns and treatment goals.
Profhilo may be particularly suitable if your main concerns are:
- •dehydration
- •loss of elasticity
- •dull skin tone
Polynucleotides may be a better option if your goals include:
- •improving delicate skin areas
- •supporting skin repair
- •improving texture and resilience
In many cases, these treatments can even complement each other, as they address different aspects of skin health.
How Long Do Results Last?
Both treatments work gradually by stimulating natural biological processes.
Most treatment plans involve an initial course of two sessions, spaced a few weeks apart.
After this, results typically develop over several weeks as the skin begins producing more collagen and improving its hydration levels.
Depending on the individual and the treatment used, results may last several months, after which maintenance sessions can help prolong the effects.
Choosing the Right Treatment for Your Skin
Because every person's skin is different, the best way to determine the right treatment is through a professional consultation.
An experienced practitioner can assess factors such as:
- •skin quality
- •areas of concern
- •overall treatment goals
If you are considering Profhilo and would like to understand the full treatment process, you can view the details on our Profhilo in Fulham page. For polynucleotides, you can read about our approach on the polynucleotides treatment page.
This helps ensure the chosen treatment supports the natural health and appearance of the skin rather than simply masking concerns.
Not sure which treatment is right for you?
Describe your skin concerns and our treatment assistant will suggest suitable treatments. You can also message us on WhatsApp for personalised advice.
Message us on WhatsAppSkin Treatments in Fulham, London
Advanced skin treatments such as polynucleotides and other regenerative therapies are available at a private studio in South Park Studios, Fulham (SW6).
These treatments focus on improving skin quality while maintaining natural facial harmony.
If you would like advice about your skin or want to explore which treatment might be suitable, you can book a consultation or send a message for guidance.